Thursday 13th November 2025

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Moderately to severely immunocompromised people with certain medical conditions may receive a third dose of a Pfizer or Moderna COVID-19 vaccine.

According to the Missouri Department of Health and Senior Services (DHSS), Missouri will use a self-attestation model that is in line with federal guidelines, so individuals will not be required to provide documentation of their health status.

Medical conditions and treatments that qualify individuals include, but are not limited to:
– Solid organ transplant and taking immune suppressing medications;
– Active treatment for solid tumor and hematologic malignancies;
– CAR-T cell or hematopoietic stem cell transplant (within two years of transplantation or taking immunosuppression therapy);
– Primary immunodeficiency (eg., DiGeorge, Wiskott-Aldrich Syndromes);
– Advanced or untreated HIV infection; or
– Active treatment with high-dose corticosteroids or other drugs that may suppress immune response: high dose corticosteroids (ie.,= 20 mg prednisone or equivalent per day), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, tumor-necrosis (TNF) blocker or other biologic agents that are immunosuppressive or immunomodulatory.

Vaccine providers and events in Missouri can be found at MOStopsCovid.com.

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